a Wiley Company Incorporated On behalf of the Society for Leukocyte Biology SLB by Wiley Subscription Services

Human Blood CD1c Dendritic Cells Stimulate IL-12-independent IFN-γ Responses and Have a Strikingly

Get Access Human Blood CD1c Dendritic Cells Stimulate IL-12-independent IFN-γ Responses and Have a Strikingly Low Inflammatory Profile by eBook in format PDF,ePub,Kindle and Audiobook

Human Blood CD1c Dendritic Cells Stimulate IL-12-independent IFN-γ Responses and Have a Strikingly Low Inflammatory Profile

Author :

Publisher : On behalf of the Society for Leukocyte Biology (SLB) by Wiley Subscription Services, Incorporated, a Wiley Company

Published : 2015

ISBN-10 :

ISBN-13 :

Number of Pages : Pages

Language : en

Descriptions Human Blood CD1c Dendritic Cells Stimulate IL-12-independent IFN-γ Responses and Have a Strikingly Low Inflammatory Profile

Keyword :

Read Online Human Blood CD1c Dendritic Cells Stimulate IL-12-independent IFN-γ Responses and Have a Strikingly Low Inflammatory Profile pdf

Download Human Blood CD1c Dendritic Cells Stimulate IL-12-independent IFN-γ Responses and Have a Strikingly Low Inflammatory Profile epub

Human Blood CD1c Dendritic Cells Stimulate IL-12-independent IFN-γ Responses and Have a Strikingly Low Inflammatory Profile Audiobook Download

Listen Human Blood CD1c Dendritic Cells Stimulate IL-12-independent IFN-γ Responses and Have a Strikingly Low Inflammatory Profile book

Download Human Blood CD1c Dendritic Cells Stimulate IL-12-independent IFN-γ Responses and Have a Strikingly Low Inflammatory Profile Audiobook

An electronic book, also known as an e-book or eBook, is a book publication made available in digital form, consisting of text, images, or both, readable on the flat-panel display of computers or other electronic devices. Although sometimes defined as "an electronic version of a printed book",some e-books exist without a printed equivalent. E-books can be read on dedicated e-reader devices, but also on any computer device that features a controllable viewing screen, including desktop computers, laptops, tablets and smartphones.

Results Human Blood CD1c Dendritic Cells Stimulate IL-12-independent IFN-γ Responses and Have a Strikingly Low Inflammatory Profile

Human dendritic cells in cancer | Science Immunology - Abstract. Dendritic cells (DCs) are professional antigen-presenting cells, orchestrating innate and adaptive immunity during infections, autoimmune diseases, and malignancies. Since the discovery of DCs almost 50 years ago, our understanding of their biology in humans has increased substantially. Here, we review both antitumor and tolerogenic

(PDF) Human CD1c+ dendritic cells secrete high levels of IL-12 and - In conclusion, CD1c(+)mDC1 are the relevant source of IL-12 for naive T cells and are fully equipped to cross-prime cytotoxic T-cell responses. Frequency and proliferation of human DC subsets in

The clinical application of cancer immunotherapy based on naturally - Characterization of human blood dendritic cell subsets. Blood. 2002;100(13):4512-20. Article CAS PubMed Google Scholar Nizzoli G, Krietsch J, Weick A, Steinfelder S, Facciotti F, Gruarin P, et al. Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently - Here we compared CD1c(+) myeloid DC (mDC)1, BDCA-3(+)mDC2, and plasmacytoid DC (pDC) in peripheral blood and lymphoid tissues for phenotype, cytokine production, and their capacities to prime cytotoxic T cells. mDC1 were surprisingly the only human DC that secreted high amounts of IL-12p70, but they required combinational Toll-like receptor

Profoundly Reduced CD1c+ Myeloid Dendritic Cell HLA-DR and ... - PubMed - Profoundly Reduced CD1c+ Myeloid Dendritic Cell HLA-DR and CD86 Expression and Increased Tumor Necrosis Factor Production in Experimental Human Blood-Stage Malaria Infection Infect Immun. 2016 Apr 22 ... (TNF), whereas interleukin-12 (IL-12) production was unchanged. Interestingly, only the 1,800-pRBC dose caused a reduction in the circulating

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently - Abstract. Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice, CD8α + DC are specialized to cross-prime CD8 + T cells and produce interleukin-12 (IL-12) that promotes cytotoxicity. Human BDCA-3 + DC share several relevant characteristics with CD8α + DC, but the capacities of human DC subsets to induce CD8 + T-cell responses are incompletely understood

Human blood CD1c dendritic cells stimulate IL-12-independent IFN- - Although much accepted human myeloid DC cell biology is based on moDC studies, we find these 2 DC populations to be functionally distinct. Stimulated moDC produce high levels of IL-10 and the Th1-promoting cytokine IL-12. Under identical conditions, CD1c DC synthesized no IL-10 and no or low levels of IL-12

Human blood CD1c dendritic cells stimulate IL-12-independent IFN - Request PDF | Human blood CD1c dendritic cells stimulate IL-12-independent IFN- responses and have a strikingly low inflammatory profile | Adaptive immune responses are initiated by resident

Tolerogenic Dendritic Cells in Autoimmunity and Inflammatory Diseases - Dendritic cells (DCs), the most efficient antigen-presenting cells, are necessary for the effective activation of naïve T cells. DCs can also acquire tolerogenic functions in vivo and in vitro in response to various stimuli, including interleukin (IL)-10, transforming growth factor (TGF)-β, vitamin D3, corticosteroids, and rapamycin. In this review, we provide a wide perspective on the

Dendritic Cell-Based Cancer Vaccines | The Journal of Immunology - IL-12 secretion BDCA-1 (CD1c) + ... culture and resultant phenotype are stable enough to resist strong maturation signals from the TLR ligand LPS and can increase inhibitory checkpoint molecule ... Granulocyte-macrophage colony-stimulating factor promotes differentiation and survival of human peripheral blood dendritic cells in vitro

Subsets of CD1c + DCs: Dendritic Cell Versus Monocyte Lineage - PubMed - Abstract. Currently three bona fide dendritic cell (DC) types are distinguished in human blood. Herein we focus on type 2 DCs (DC2s) and compare the three defining markers CD1c, CD172, and CD301. When using CD1c to define DC2s, a CD14 + and a CD14 - subset can be detected. The CD14 + subset shares features with monocytes, and this includes

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently - Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice, CD8α + DC are specialized to cross-prime CD8 + T cells and produce interleukin-12 (IL-12) that promotes cytotoxicity. Human BDCA-3 + DC share several relevant characteristics with CD8α + DC, but the capacities of human DC subsets to induce CD8 + T-cell responses are incompletely understood

Human dendritic cell subsets: an update - Wiley Online Library - IL-12 pDC cDC1 XCL1 XCL1 cDC2 IL-12 CD5lo CD5hi Figure 1. Ontological overview and functional specialization of human dendritic cells (DC). (a) DC are often depicted as a single 'all purpose' cell in diagrams of T-cell differentiation but each subset is specialized to make speciﬁc responses to pathogen or danger signals. Depending on

Human blood CD1c dendritic cells stimulate IL-12-independent IFN- γ - Journal of Leukocyte Biology 97(5): 873-885

Human plasmacytoid dendritic cells express the functional ... - Springer - Human blood pDCs express CD39 and CD73. Human blood pDCs were purified by a double-positive magnetic cell sorting with anti-BDCA-4 antibodies. Their phenotype was analyzed in the 7-AAD negative gate (living cells) based on BDCA-2, CD123, CD4, and CD33 expression (Fig. 1a). Pure pDCs were characterized as BDCA-4 +, BDCA-2 +, CD123 +, CD4 +, and CD33 − cells

Human Macrophages and Monocyte-Derived Dendritic Cells Stimulate the - Human Macrophages and Monocyte-Derived Dendritic Cells Stimulate the Proliferation of Endothelial Cells through Midkine Production . × Close Log In. Log in with Facebook Log in with Google. or. Email. Password. Remember me on this computer. or reset password. Enter the email address you signed up with and we'll email you a reset link

Coexpression of CD163 and CD141 identifies human circulating IL-10 - Tolerogenic dendritic cells (DCs) are key players in maintaining immunological homeostasis, dampening immune responses, and promoting tolerance. DC-10, a tolerogenic population of human IL-10

Dendritic Cell Overview | Thermo Fisher Scientific - US - Additional monocyte-derived cells (MCs) with DC-like properties (moDCs) can be generated during pathogen-initiated inflammation via the differentiation of monocytes [ 6 ]. Figure 2. Dendritic cell development. Dendritic cells (DCs) develop from hematopoietic stem cells (HSCs) in a multistep process that begins in the bone marrow

Human blood CD1c dendritic cells stimulate IL‐12‐independent IFN‐γ - Human blood CD1c dendritic cells stimulate IFNγ response independent of IL-12, in contrast to the IL-12-dependent response when mediated by monocyte-derived dendritic cells. Adaptive immune

Human blood CD1c dendritic cells stimulate IL‐12‐independent IFN‐ γ - Article Human blood CD1c dendritic cells stimulate IL-12-independent IFN-g responses and have a strikingly low inflammatory profile Adel Benlahrech,* Sai Duraisingham,* Douglas King,† Lisa Verhagen,* George Rozis,* Parisa Amjadi,‡ Tom Ford,* Peter Kelleher,*,§ and Steven Patterson*,1 *Centre for Immunology and Vaccinology, Imperial College London, Chelsea and Westminster Hospital, London

CD1c-Expression by Monocytes - Implications for the Use of ... - PLOS - Conventional dendritic cells (cDCs) comprise a heterogeneous population of cells that are important regulators of immunity and homeostasis. CD1c+ cDCs are present in human blood and tissues, and found to efficiently activate naïve CD4+ T cells. While CD1c is thought to specifically identify this subset of human cDCs, we show here that also classical and intermediate monocytes express CD1c

Blood Dendritic Cell - an overview | ScienceDirect Topics - The blood dendritic cell antigen 2, or Clec4C. Blood DC antigen 2 (BDCA-2) is a type II C-type lectin found in human pDCs. As with most Dectin-2 family members, BDCA-2 signaling relies on the ITAM sequence in the FcRγ chain leading to signaling through Syk, phospholipase C-gamma (PLCγ2), Vav1, and Erk1/2. BDCA-2 signaling inhibits the

Human blood CD1c dendritic cells stimulate IL‐12‐independent IFN‐γ - Although much accepted human myeloid DC cell biology is based on moDC studies, we find these 2 DC populations to be functionally distinct. Stimulated moDC produce high levels of IL‐10 and the Th1‐promoting cytokine IL‐12. Under identical conditions, CD1c DC synthesized no IL‐10 and no or low levels of IL‐12

Dendritic Cells - The Impact of Food Bioactives on Health - NCBI Bookshelf - Dendritic cells (DCs) are the sentinels of the immune system and play a critical role in stimulating immune responses against pathogens and maintaining immune homeostasis to harmless antigens. They can be found in all lymphoid and most non-lymphoid tissues, including mucosal surfaces, like the lung and the gut, where intricate networks of DCs are situated to sense potential harmful exposures

Conventional Type 1 Dendritic Cells (cDC1) in Human Kidney Diseases - Dendritic cells can be broadly categorized into plasmacytoid DCs (pDC) and conventional DCs (cDC). cDC consists of two major subsets: cDC1 (CD141 + DCs in humans and CD103 + or CD8α + DCs in rodents) and cDC2 (CD1c + DCs in human and CD11b + DCs in rodents) . cDC1 were discovered first in mouse and then in humans and are characterized by their

What are the best markers for immature Dendritic cells derived from - We also check CD80 and HLA-DR, CD11c high. Cite. 19th Mar, 2014. Philippe Pierre. You should see a loss of CD14 on floating cells, Typically MHC II should be dim to high and be up regulated

PDF Human CD1c+ dendritic cells secrete high levels of IL-12 and potently - Human CD1c1 dendritic cells secrete high levels of IL-12 and potently ... source of IL-12 for naive T cells and are fully equipped to cross-prime cytotoxic T-cell responses. (Blood. 2013;122(6

Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display - Human blood myeloid DCs can be subdivided into CD1c (BDCA-1)(+) and CD141 (BDCA-3)(+) subsets that display unique gene expression profiles, suggesting specialized functions. CD1c(+) DCs express TLR4 while CD141(+) DCs do not, thus predicting that these two subsets have differential capacities to res …

Human blood CD1c dendritic cells stimulate IL-12-independent IFN- - CD1c DC from a patient with a highly reduced ability to produce IL-12 stimulate T cells to produce IFN-γ. The ability of moDC and CD1c DC, cultured for 40 h in GM-CSF and IL-4 from an IL-12-deficient patient, to produce IL-12p70 and p40 and mediate IFN-γ production in allogeneic T cells. (A) IL-12 p70 and p40 production from healthy (closed

Human blood CD1c dendritic cells stimulate IL‐12‐independent - Human CD1c blood DC, monocytes, and lymphocytes were isolated from buffy coats or apheresis cones purchased from the North London Blood Transfusion Service (Colindale, United Kingdom). For some experiments, CD1c and moDC were isolated from an IL-12-deﬁcient patient. PBMCs were centrifuged with .50% percoll to generate monocyte/DC-enriched

Human CD1c+ dendritic cells secrete high levels of IL-12 and - Abstract. Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice, CD8α (+)DC are specialized to cross-prime CD8 (+) T cells and produce interleukin-12 (IL-12) that promotes cytotoxicity. Human BDCA-3 (+)DC share several relevant characteristics with CD8α (+)DC, but the capacities of human DC subsets to

Human blood CD1c dendritic cells stimulate IL‐12‐independent - CD1c DC from a patient with a highly reduced ability to produce IL-12 stimulate T cells to produce IFN-γ. The ability of moDC and CD1c DC, cultured for 40 h in GM-CSF and IL-4 from an IL-12-deficient patient, to produce IL-12p70 and p40 and mediate IFN-γ production in allogeneic T cells. (A) IL-12 p70 and p40 production from healthy (closed

- Stimulated moDC produce high levels of IL-10 and the Th1-promoting cytokine IL-12. Under identical conditions, CD1c DC synthesized no IL-10 and no or low levels of IL-12. Despite this, CD1c DC stimulated a strong Th1 response, demonstrated by IL-12 neutralization to be IL-12 independent, whereas the response induced by moDC was IL-12 dependent

Frontiers | Human Dendritic Cell Subsets, Ontogeny, and - What is a CD1c+ dendritic cell?

Human CD1c+ dendritic cells secrete high levels of IL-12 and - Dendritic cells (DC) are professional antigen-presenting cells (APC) that possess the unique capacity to trigger primary adaptive immune responses through the antigen-specific activation of naive CD4 + and CD8 + T cells. 1 DC are derived from proliferating precursors in the bone marrow that migrate via the blood to lymphoid and nonlymphoid

Human blood CD1c dendritic cells stimulate IL-12-independent - Although much accepted human myeloid DC cell biology is based on moDC studies, we find these 2 DC populations to be functionally distinct. Stimulated moDC produce high levels of IL-10 and the Th1-promoting cytokine IL-12. Under identical conditions, CD1c DC synthesized no IL-10 and no or low levels of IL-12